![]() Most common adverse effects of systemic steroids are weight gain, fluid retention, stomach upset/acidity, osteoporosis, increased appetite, acne, facial puffiness/moon facies, diabetes mellitus/alteration of glucose tolerance, hypertension, mood changes, and increased susceptibility to infection. Though steroids (glucocorticoids) both topical and systemic are very important for acute control of active uveitis, long-term use of steroids can cause various side effects. These agents are thought to re-educate the immune system to a level that the recurrent autoimmune inflammation of ocular tissues are prevented. In ocular inflammation, they are used as steroid-sparing agents to control the inflammation with a target for durable remission and prevention of sight-threatening complications of uveitis. These drugs have been used to prevent rejection of transplants and these are used as chemotherapy for cancers. On the other hand, immunosuppressant has been defined by the Collins dictionary as 'any drug or substance that suppresses the immune response'. The Merriam-Webster's dictionary defines immunomodulator as 'a chemical agent (as methotrexate or azathioprine) that modifies the immune response or the functioning of the immune system (as by the stimulation of antibody formation or the inhibition of white blood cell activity)'. 1.7 Expected onset of anti-inflammatory actionÄefinition (Immunomodulators and immunosuppressants).1.6 Baseline tests and follow-up tests for IMT.1 Definition (Immunomodulators and immunosuppressants). ![]()
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